Production of superoxide anions by a CNS macrophage, the microglia
- 2 November 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 223 (2), 284-288
- https://doi.org/10.1016/0014-5793(87)80305-8
Abstract
Microglia have been implicated in both physiological and pathological processes of the brain. Their possible roles have been compared to those of macrophages and granulocytes. Here we demonstrate the specific ability of microglia to secrete the superoxide radical ion in response to a complement activated agent, opsonized zymosan, and to phorbol myristate acetate. As in other organs, this endogenously produced reactive oxygen intermediate could have both beneficial and deleterious effects.This publication has 31 references indexed in Scilit:
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