Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Top Cited Papers
Open Access
- 30 July 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 369 (6503), 582-+
- https://doi.org/10.1126/science.abb9263
Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology of SARS-CoV-2 in Northern California from late January tomid-March 2020, using samples from 36 patients spanning nine counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least seven different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington state, with lack of a predominant lineage and limited transmission among communities. Lineages associated with outbreak clusters in two counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain the spread of SARS-CoV-2 in California and other states.Funding Information
- National Institutes of Health (R33AI129455)
- National Institutes of Health (K08CA230156)
- National Institute of Allergy and Infectious Diseases (U19AI135995)
- Medical Research Council (MR/S0195/1)
- Wellcome Trust Centre for Mitochondrial Research (204311/Z/16/Z)
- Charles and Helen Schwab Foundation
- Burroughs-Wellcome CAMS Award
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