Recent Updates on Outbreaks of Shiga Toxin-Producing Escherichia coli and Its Potential Reservoirs
Open Access
- 4 June 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cellular and Infection Microbiology
- Vol. 10, 273
- https://doi.org/10.3389/fcimb.2020.00273
Abstract
Following infection with certain strains of Shiga toxin-producing Escherichia coli (STEC), particularly enterohemorrhagic ones, patients are at elevated risk for developing life-threatening extraintestinal complications, such as acute renal failure. Hence, these bacteria represent a public health concern in both developed and developing countries. Shiga toxins (Stxs) expressed by STEC are highly cytotoxic class II ribosome-inactivating proteins and primary virulence factors responsible for major clinical signs of Stx-mediated pathogenesis, including bloody diarrhea, hemolytic uremic syndrome (HUS), and neurological complications. Ruminant animals are thought to serve as critical environmental reservoirs of Stx-producing Escherichia coli (STEC), but other emerging or arising reservoirs of the toxin-producing bacteria have been overlooked. In particular, a number of new animal species from wildlife and aquaculture industries have recently been identified as unexpected reservoir or spillover hosts of STEC. Here, we summarize recent findings about reservoirs of STEC and review outbreaks of these bacteria both within and outside the United States. A better understanding of environmental transmission to humans will facilitate the development of novel strategies for preventing zoonotic STEC infection.Keywords
Funding Information
- Korea Research Institute of Bioscience and Biotechnology
- Ministry of Education
This publication has 129 references indexed in Scilit:
- Zoonosis emergence linked to agricultural intensification and environmental changeProceedings of the National Academy of Sciences of the United States of America, 2013
- Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx NomenclatureJournal of Clinical Microbiology, 2012
- Norwegian Sheep Are an Important Reservoir for Human-Pathogenic Escherichia coli O26:H11Applied and Environmental Microbiology, 2012
- Seropathotypes, Phylogroups, Stx Subtypes, and Intimin Types of Wildlife-Carried, Shiga Toxin-Producing Escherichia coli Strains with the Same Characteristics as Human-Pathogenic IsolatesApplied and Environmental Microbiology, 2012
- Differential Response of the Human Renal Proximal Tubular Epithelial Cell Line HK-2 to Shiga Toxin Types 1 and 2Infection and Immunity, 2011
- From “one medicine” to “one health” and systemic approaches to health and well-beingPreventive Veterinary Medicine, 2011
- Escherichia coliO157:H7: Animal Reservoir and Sources of Human InfectionFoodborne Pathogens & Disease, 2011
- Prevalence and Characteristics of eae - and stx -Positive Strains of Escherichia coli from Wild Birds in the Immediate Environment of Tokyo BayApplied and Environmental Microbiology, 2009
- Global trends in emerging infectious diseasesNature, 2008
- Pathogenic Escherichia coliNature Reviews Microbiology, 2004