Serum Visfatin Increases With Progressive β-Cell Deterioration
- 1 October 2006
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 55 (10), 2871-2875
- https://doi.org/10.2337/db06-0259
Abstract
Visfatin has shown to be increased in type 2 diabetes but to be unrelated to insulin sensitivity. We hypothesized that visfatin is associated with insulin secretion in humans. To this aim, a cross-sectional study was conducted in 118 nondiabetic men and 64 (35 men and 29 women) type 2 diabetic patients. Type 1 diabetic patients with long-standing disease (n = 58; 31 men and 27 women) were also studied. In nondiabetic subjects, circulating visfatin (enzyme immunoassay) was independently associated with insulin secretion (acute insulin response to glucose [AIRg] from intravenous glucose tolerance tests) but not with insulin sensitivity (Si) or other metabolic or anthropometric parameters, and AIRg alone explained 8% of visfatin variance (β = −0.29, P = 0.001). Circulating visfatin was increased in type 2 diabetes (mean 18 [95% CI 16–21] vs. 15 ng/ml [13–17] for type 2 diabetic and nondiabetic subjects, respectively; P = 0.017, adjusted for sex, age, and BMI), although this association was largely attenuated after accounting for HbA1c (A1C). Finally, circulating visfatin was found to be increased in patients with long-standing type 1 diabetes, even after adjusting for A1C values (37 ng/ml [34–40]; P < 0.0001, adjusted for sex, age, BMI, and A1C compared with either type 2 diabetic or nondiabetic subjects). In summary, circulating visfatin is increased with progressive β-cell deterioration. The study of the regulation and role of visfatin in diabetes merits further consideration.Keywords
This publication has 19 references indexed in Scilit:
- Reduced Plasma Visfatin/Pre-B Cell Colony-Enhancing Factor in Obesity Is Not Related to Insulin Resistance in HumansJournal of Clinical Endocrinology & Metabolism, 2006
- Genetic Variation in the Visfatin Gene (PBEF1) and Its Relation to Glucose Metabolism and Fat-Depot-Specific Messenger Ribonucleic Acid Expression in HumansJournal of Clinical Endocrinology & Metabolism, 2006
- The release of the adipocytokine visfatin is regulated by glucose and insulinDiabetologia, 2006
- Increased visfatin concentrations in women with gestational diabetes mellitusClinical Science, 2006
- Visfatin Is an Adipokine, But It Is Not Regulated by ThiazolidinedionesJournal of Clinical Endocrinology & Metabolism, 2006
- β-Cell Function in Morbidly Obese Subjects During Free LivingDiabetes, 2005
- Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytesJournal of Endocrinology, 2005
- Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of InsulinScience, 2005
- Glucose toxicityEndocrine Reviews, 1992
- The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDMDiabetes, 1988