Low-Dose Oral Use of Human Interferon-alpha in Cancer Patients
- 1 August 1999
- journal article
- clinical trial
- Published by Mary Ann Liebert Inc in Journal of Interferon & Cytokine Research
- Vol. 19 (8), 937-941
- https://doi.org/10.1089/107999099313488
Abstract
In a double-blind placebo-controlled trial, 57 adult subjects with disseminated malignancies were given orally low doses of recombinant human interferon-alpha (rHuIFN-alpha) at 0.05 IU, 0.5 IU, or 5.0 IU/kg body weight. The objective was to determine the efficacy of orally administered rHuIFN-alpha on appetite stimulation and/or weight loss prevention in anorectic cancer patients. Almost two-thirds (64%) of the subjects given 5.0 IU/kg reported an increase in appetite or body weight after 5 weeks in contrast to only 29% of the placebo-treated subjects. However, at the end of the 91-day trial, no significant differences in appetite enhancement or weight gain were noted between these two groups. Additionally, the 5.0 IU/kg treated group experienced half as many deaths as the control group by the conclusion of this 91-day trial.Keywords
This publication has 19 references indexed in Scilit:
- Aerosol application of interferon-alpha in the treatment of bronchioloalveolar carcinomaEuropean Journal of Cancer and Clinical Oncology, 1990
- Interferon alpha‐2a in cutaneous T‐cell lymphomaEuropean Journal of Haematology, 1990
- Relationship between immunological phenotype and hematological response to α‐IFN treatment in 35 patients with hairy cell leukemiaEuropean Journal of Haematology, 1990
- The Potential of Interferons in Malignant DiseaseDrugs, 1990
- Pharmacokinetics and Toxicity of Inhaled Human Interferon-α in Patients with Lung CancerJournal of Interferon Research, 1989
- THE EVOLVING ROLE OF ALPHA INTERFERON IN THE TREATMENT OF MALIGNANCIESAustralian and New Zealand Journal of Medicine, 1986
- Hematologic Remission and Cytogenetic Improvement Induced by Recombinant Human Interferon AlphaAin Chronic Myelogenous LeukemiaNew England Journal of Medicine, 1986
- Phase II study of recombinant leukocyte a interferon (rIFN-αA) in disseminated malignant melanomaCancer, 1984
- Treatment of Advanced Non-Hodgkin's Lymphoma with Recombinant Leukocyte a InterferonNew England Journal of Medicine, 1984
- Alpha Interferon for Induction of Remission in Hairy-Cell LeukemiaNew England Journal of Medicine, 1984