Diagnostic performance of 18F-FDG PET/CT in patients with fever of unknown origin
- 1 July 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Nuclear Medicine Communications
- Vol. 34 (7), 682-688
- https://doi.org/10.1097/mnm.0b013e328361cd0e
Abstract
The aim of this study was to systematically review and perform a meta-analysis of published data on the diagnostic value of F-fluorodeoxyglucose (F-FDG) PET/CT in the diagnosis of patients with fever of unknown origin (FUO). A comprehensive computer literature search of studies published through 31 March 2012 on the use of F-FDG PET/CT in patients with FUO was performed in PubMed/MEDLINE, Embase, and Scopus databases. The pooled sensitivity of F-FDG PET/CT in patients with FUO on a per-patient-based analysis was calculated. The area under the receiver-operating characteristic curve was calculated to measure the accuracy of F-FDG PET/CT in the diagnosis of patients with FUO. Fifteen studies comprising 595 patients with FUO were included in this meta-analysis. The pooled sensitivity of F-FDG PET/CT in detecting the cause of FUO was 85% (95% confidence interval 81-88%) on a per-patient-based analysis. The area under the receiver-operating characteristic curve was 0.88. F-FDG PET/CT demonstrated high sensitivity for the diagnosis of patients with FUO. F-FDG PET/CT is an accurate technique in this setting, but the possibility of false-positive results should be kept in mind. This meta-analysis demonstrated the value of F-FDG PET/CT in the diagnosis of patients with FUO.Keywords
This publication has 19 references indexed in Scilit:
- Enlargement of the spleen as an incidental finding on CT in post-partum females with feverThe British Journal of Radiology, 2012
- [18F] FDG PET/CT in patients with fever of unknown origin: a local experienceNuclear Medicine Communications, 2010
- F-18 FDG PET/CT in the Diagnosis of Fever of Unknown OriginClinical Nuclear Medicine, 2009
- F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infectionIntensive Care Medicine, 2009
- Clinical value of FDG-PET/CT for the diagnosis of human immunodeficiency virus-associated fever of unknown origin: a retrospective studyNuclear Medicine Communications, 2009
- Fever of Unknown Origin: The Role of 18F-FDG PET/CTJournal of Nuclear Medicine, 2008
- Evaluation of QUADAS, a tool for the quality assessment of diagnostic accuracy studiesBMC Medical Research Methodology, 2006
- Applications of fluorodeoxyglucose-PET imaging in the detection of infection and inflammation and other benign disordersRadiologic Clinics of North America, 2005
- Fever of unknown origin: prospective comparison of diagnostic value of 18 F-FDG PET and 111 In-granulocyte scintigraphyEuropean Journal of Nuclear Medicine and Molecular Imaging, 2004
- Fever of Unknown OriginArchives of Internal Medicine, 1992