Mechanisms and Regulation of the Gene-Expression Response to Sepsis
- 1 June 2010
- journal article
- review article
- Published by American Academy of Pediatrics (AAP)
- Vol. 125 (6), 1248-1258
- https://doi.org/10.1542/peds.2009-3274
Abstract
Sepsis is defined as the systemic inflammatory response of the human host that is triggered by an invading pathogen. Despite tremendous advances in both our knowledge of and treatment strategies for this syndrome, sepsis remains among the major causes of morbidity and mortality in children worldwide. Thus, we hypothesize that an improved mechanistic understanding obtained via basic and translational science will continue to identify novel therapeutic targets and approaches. As a result, given the central importance of the alterations in gene expression in regulating the human host's physiologic response to a pathogen, we review the complex factors—genetics, transcriptional expression, and epigenetics—that regulate unique gene-expression patterns in pediatric sepsis and septic shock. We anticipate that emerging data from genetic, genomic, and other translation studies in pediatric sepsis will advance our biological understanding of this response and undoubtedly identify targets for newer therapies.Keywords
This publication has 92 references indexed in Scilit:
- Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock*Pediatric Critical Care Medicine, 2010
- Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum*Critical Care Medicine, 2009
- Stratification is the key: Inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis*Critical Care Medicine, 2009
- Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis*Critical Care Medicine, 2009
- Functional Significance of Gene Polymorphisms in the Promoter of Myeloid Differentiation-2Annals of Surgery, 2007
- Stability and flexibility of epigenetic gene regulation in mammalian developmentNature, 2007
- The Pathophysiology and Treatment of SepsisNew England Journal of Medicine, 2003
- Proposed guidelines for papers describing DNA polymorphism-disease associationsHuman Genetics, 2002
- Genetics of susceptibitlity to human infectious diseaseNature Reviews Genetics, 2001
- Translating the Histone CodeScience, 2001