The Use of Polarized Laser Light Through the Eye for Noninvasive Glucose Monitoring
- 1 June 1999
- journal article
- research article
- Published by Mary Ann Liebert Inc in Diabetes Technology & Therapeutics
- Vol. 1 (2), 135-143
- https://doi.org/10.1089/152091599317341
Abstract
Background: In order to optimally manage diabetes mellitus, it is recommended blood glucose levels be monitored several times daily so an appropriate action can be taken to maintain tight control of these levels within a normal physiological range. All commercially available devices to measure blood glucose concentrations require the extraction of a drop of blood, normally obtained via the lancing of a finger. The main drawback to this method is the pain, often leading to low patient compliance. Therefore, a noninvasive glucose sensing method would greatly facilitate the management of diabetes. Methods: In this article, we describe in vitro and in vivo results from a laser-based optical polarimetry system using the anterior chamber of the eye as a potential method to noninvasively monitor glucose levels in the body. Results: It is shown, in vitro, that glucose can be predicted in the presence of albumin at physiological levels and, through the use of a novel light coupling mechanism, it is demonstrated that a polarimetric signal can be detected, in vivo, through a rabbit eye. Conclusions: Although the commercial production of a feasible noninvasive glucose monitoring method is still years away, laser-based polarimetry remains a viable alternative due to its potential to extract concentration information using the eye as a unique optical window into the body.Keywords
This publication has 18 references indexed in Scilit:
- Noninvasive Blood Glucose MonitoringDiabetes Care, 1997
- Amplitude Sensitive Optical Heterodyne and Phase Lock-in Technique on Small Optical Rotation Angle Detection of Chiral LiquidJapanese Journal of Applied Physics, 1997
- Noninvasive glucose sensing utilizing a digital closed-loop polarimetric approachIEEE Transactions on Biomedical Engineering, 1997
- Simultaneous Measurements of Glucose, Glutamine, Ammonia, Lactate, and Glutamate in Aqueous Solutions by Near-Infrared SpectroscopyApplied Spectroscopy, 1996
- Noninvasive optical polarimetric glucose sensing using a true phase measurement techniqueIEEE Transactions on Biomedical Engineering, 1992
- Increased Glucose Content in the Aqueous Humour Caused by the Use of XylazineOphthalmic Research, 1990
- Alterations of Glucose Levels in the Blood and the Anterior Eye Segment of Rabbits Exposed to Ketamine-Xylazine AnaesthesiaOphthalmic Research, 1987
- The Composition and Optical Rotary Dispersion of Bovine Aqueous HumorDiabetes Care, 1982
- Photoelectric Polarimeter using the Faraday EffectNature, 1956