Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer
Top Cited Papers
- 1 April 2009
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 15 (7), 2207-2214
- https://doi.org/10.1158/1078-0432.ccr-08-1306
Abstract
Purpose: Gemcitabine is a promising adjuvant treatment for patients with resected pancreatic adenocarcinoma and its use in combination with radiotherapy is under exploration. Human equilibrative nucleoside transporter 1 (hENT1) and human concentrative nucleoside transporter (hCNT) 1 and 3 are the major transporters responsible for 2′,2′-difluoro-2-deoxycytidine (gemcitabine) uptake into cells. The aim of this study was to determine patients' outcome according to the expression of hENT1 and hCNT3 in tumoral cells after postoperative gemcitabine-based chemoradiation regimen.Keywords
This publication has 66 references indexed in Scilit:
- Signaling networks assembled by oncogenic EGFR and c-MetProceedings of the National Academy of Sciences of the United States of America, 2008
- The Met tyrosine kinase receptor in development and cancerCancer and Metastasis Reviews, 2008
- MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinibProceedings of the National Academy of Sciences of the United States of America, 2007
- The shadow of death on the MET tyrosine kinase receptorCell Death & Differentiation, 2007
- MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 SignalingScience, 2007
- Antibody validation by quantitative analysis of protein expression using expression of Met in breast cancer as a modelLaboratory Investigation, 2007
- A Novel One-Armed Anti-c-Met Antibody Inhibits Glioblastoma Growth In vivoClinical Cancer Research, 2006
- Improved gene transfer selectivity to hepatocarcinoma cells by retrovirus vector displaying single-chain variable fragment antibody against c-MetCancer Gene Therapy, 2003
- Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cellsBritish Journal of Pharmacology, 2003
- Scatter-factor and semaphorin receptors: cell signalling for invasive growthNature Reviews Cancer, 2002