Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium
- 1 May 2004
- journal article
- Published by Elsevier BV in Journal of Biotechnology
- Vol. 110 (2), 171-179
- https://doi.org/10.1016/j.jbiotec.2004.02.004
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- Analysis of CHO Cells Metabolic Redistribution in a Glutamate-Based Defined Medium in Continuous CultureBiotechnology Progress, 2001
- Decoupling cell growth and product formation in Chinese hamster ovary cells through metabolic controlBiotechnology & Bioengineering, 2001
- Improvement of CHO Cell Culture Medium Formulation: Simultaneous Substitution of Glucose and GlutamineBiotechnology Progress, 2000
- Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reactionBiotechnology & Bioengineering, 1999
- Methods for reducing the ammonia in hybridoma cell culturesJournal of Biotechnology, 1995
- Increase of Productivity in Recombinant Cho-Cells by Enhanced Glucose-LevelsPublished by Springer Science and Business Media LLC ,1995
- Determination of ammonium and L-Glutamine in hybridoma cell cultures by sequential flow injection analysisCytotechnology, 1994
- Influence of Ammonium on Growth, Metabolism, and Productivity of a Continuous Suspension Chinese Hamster Ovary Cell CultureBiotechnology Progress, 1994
- Fed-batch culture of hybridoma cells: comparison of optimal control approach and closed loop strategiesBioprocess and Biosystems Engineering, 1993
- Mathematical descriptions of hybridoma culture kinetics. III. Simulation of fed-batch bioreactorsJournal of Biotechnology, 1989