Opioid-induced Hyperalgesia
Top Cited Papers
- 1 March 2006
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 104 (3), 570-587
- https://doi.org/10.1097/00000542-200603000-00025
Abstract
Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain and potentially may aggravate their preexisting pain. This review provides a comprehensive summary of basic and clinical research concerning opioid-induced hyperalgesia, suggests a framework for organizing pertinent information, delineates the status quo of our knowledge, identifies potential clinical implications, and discusses future research directions.Keywords
This publication has 99 references indexed in Scilit:
- Opioid hyperalgesia and tolerance versus 5-HT1A receptor-mediated inverse toleranceTrends in Pharmacological Sciences, 2003
- Intraoperative high dose fentanyl induces postoperative fentanyl toleranceCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1999
- Severe opioid toxicity and somatizationof psychosocial distress in a cancer patient with a background of chemical dependenceJournal of Pain and Symptom Management, 1997
- Cold-pressor pain tolerance in opiate and cocaine abusers: Correlates of drug type and use statusJournal of Pain and Symptom Management, 1994
- Opioid mediation of the antiaversive and hyperalgesic actions of bradykinin injected into the dorsal periaqueductal gray of the ratPhysiology & Behavior, 1992
- Comparison of subjective and objective analgesic effects of intravenous and intrathecal morphine in chronic pain patients by heat beam dolorimetryPain, 1989
- Associative morphine tolerance in the rat: Examinations of compensatory responding and cross-tolerance with stress-induced analgesiaBehavioral and Neural Biology, 1989
- A withdrawal hyperalgesia test for physical dependence: Evaluation of μ and mixed-partial opioid agonistsJournal of Pharmacological Methods, 1983
- Possible medullary κ hyperalgesic mechanism I. A new potential role for endogenous opioid peptides in pain perceptionLife Sciences, 1983
- Conditional hyperalgesia is elicited by environmental signals of morphineBehavioral and Neural Biology, 1981