Assessment of Tissue Autofluorescence and Reflectance for Oral Cavity Cancer Screening
- 29 July 2011
- journal article
- research article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 145 (6), 956-960
- https://doi.org/10.1177/0194599811416773
Abstract
Objective. Although approved by the US Food and Drug Administration for clinical use, the utility of handheld tissue reflectance and autofluorescence devices for screening head and neck cancer patients is poorly defined. There is limited published evidence regarding the efficacy of these devices. The authors investigated the sensitivity and specificity of these modalities compared with standard examination. Study Design. Prospective, cross-sectional analysis. Setting. Tertiary care medical center. Subjects and Methods. Patients who were treated previously for head and neck cancer (n = 88) between 2009 and 2010 were included. Patients were screened using white light visualization (standard of care) and compared with tissue reflectance and autofluorescence visualization. Screening results were compared with biopsy or long-term follow-up. Results. Autofluorescence visualization had a specificity of 81% and a sensitivity of 50% for detecting oral cavity cancer, whereas white light visualization had a specificity of 98% and a sensitivity of 50%. Tissue reflectance visualization had low sensitivity (0%) and good specificity (86%). The power of this study was insufficient to compare the positive and negative predictive values of standard white light examination (50% and 98%, respectively) to tissue autofluorescence (11% and 97%) or reflectance (0% and 95%). In addition, stratification by previous radiation therapy found no statistically significant difference in screening results. Conclusion. Standard clinical lighting has a higher specificity than tissue reflectance and autofluorescence visualization for detection of disease in patients with a history of head and neck cancer. This study does not support the added costs associated with these devices.Keywords
This publication has 20 references indexed in Scilit:
- Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapyPublished by Wiley ,2010
- Advances in Fluorescence Imaging Techniques to Detect Oral Cancer and Its PrecursorsFuture Oncology, 2010
- Evaluation of a low-cost, portable imaging system for early detection of oral cancerHead & Neck Oncology, 2010
- Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence ImagingCancer Prevention Research, 2009
- Local recurrences and second primary tumors from squamous cell carcinoma of the oral cavity: A retrospective analytic study of 500 patientsHead & Neck, 2009
- Noninvasive evaluation of oral lesions using depth‐sensitive optical spectroscopyCancer, 2009
- Diagnostic aids in the screening of oral cancerHead & Neck Oncology, 2009
- Understanding the Biological Basis of Autofluorescence Imaging for Oral Cancer Detection: High-Resolution Fluorescence Microscopy in Viable TissueClinical Cancer Research, 2008
- Critical evaluation of diagnostic aids for the detection of oral cancerOral Oncology, 2007
- QUANTITATIVE OPTICAL SPECTROSCOPY FOR TISSUE DIAGNOSISAnnual Review of Physical Chemistry, 1996