Combined Activity In Vitro of Caspofungin, Amphotericin B, and Azole Agents against Itraconazole-Resistant Clinical Isolates of Aspergillus fumigatus
Open Access
- 1 March 2005
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (3), 1232-1235
- https://doi.org/10.1128/aac.49.3.1232-1235.2005
Abstract
Interactions in vitro between amphotericin B, itraconazole, voriconazole, and caspofungin against itraconazole-resistant Aspergillus fumigatus clinical strains were determined. Differential results were obtained depending on the criteria (MIC or minimal effective concentration) used. Caspofungin and voriconazole exhibited the most potent interactions, with synergy against at least 50% of isolates, and the average fractional concentration index was 0.38. Antagonism was not found for any combination.Keywords
This publication has 32 references indexed in Scilit:
- Efficacy of Caspofungin Alone and in Combination with Voriconazole in a Guinea Pig Model of Invasive AspergillosisAntimicrobial Agents and Chemotherapy, 2002
- Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolateFungal Genetics and Biology, 2002
- Nationwide Survey of In Vitro Activities of Itraconazole and Voriconazole against Clinical Aspergillus fumigatus Isolates Cultured between 1945 and 1998Journal of Clinical Microbiology, 2002
- Caspofungin in Combination with Itraconazole for the Treatment of Invasive Aspergillosis in HumansClinical Infectious Diseases, 2002
- Azole Cross-Resistance in Aspergillus fumigatusAntimicrobial Agents and Chemotherapy, 2002
- In Vitro Synergy of Caspofungin and Amphotericin B against Aspergillus and Fusarium sppAntimicrobial Agents and Chemotherapy, 2002
- Acquired itraconazole resistance in Aspergillus fumigatusJournal of Antimicrobial Chemotherapy, 2001
- Influence of Glucose Supplementation and Inoculum Size on Growth Kinetics and Antifungal Susceptibility Testing of Candida sppJournal of Clinical Microbiology, 2001
- In-vivo itraconazole resistance of Aspergillus fumigatus in systemic murine aspergillosisJournal of Medical Microbiology, 1999
- In Vitro Susceptibility of Respiratory Isolates of Aspergillus species to Itraconazole and Amphotericin B. Acquired Resistance to ItraconazoleScandinavian Journal of Infectious Diseases, 1997