Imaging Findings of Invasive Micropapillary Carcinoma of the Breast
Open Access
- 1 January 2012
- journal article
- Published by Korean Breast Cancer Society in Journal of Breast Cancer
- Vol. 15 (1), 57-64
- https://doi.org/10.4048/jbc.2012.15.1.57
Abstract
The purpose of this study is to evaluate imaging and histopathologic findings including the immunohistochemical characteristics of invasive micropapillary carcinoma (IMPC) of the breast. Twenty-nine patients diagnosed with IMPC were included in the present study. Mammographic, sonographic, and magnetic resonance imaging (MRI) findings were analyzed retrospectively according to the American College of Radiology Breast Imaging Reporting and Data System lexicon. 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) findings were also evaluated. Microscopic slides of surgical specimens were reviewed in consensus by two pathologists with a specialty in breast pathology. Most IMPCs presented as a high density irregular mass with a non-circumscribed margin associated with microcalcifications on mammography, as an irregular hypoechoic mass with a spiculated margin on ultrasound, and as irregular spiculated masses with washout patterns on MRI. PET-CT showed a high maximum standardized uptake value (SUVmax) (mean, 11.2). Axillary nodal metastases were identified in 65.5% of the patients. Immunohistochemical studies showed high positivities for estrogen receptor and c-erbB-2 (93.1% and 51.7µ, respectively). Even though the imaging characteristics of IMPCs are not distinguishable from typical invasive ductal carcinomas, this tumor type frequently results in nodal metastases and high positivities for both estrogen receptor and c-erbB-2. The high SUVmax value that is apparent on PET-CT might be helpful in the diagnosis of IMPC.Keywords
This publication has 26 references indexed in Scilit:
- Invasive Micropapillary Carcinoma of the Breast: Mammographic, Sonographic, and MRI FeaturesAmerican Journal of Roentgenology, 2009
- Association between [18F]fluorodeoxyglucose uptake and prognostic parameters in breast cancerBritish Journal of Surgery, 2009
- Clinicopathological and Prognostic Relevance of Uptake Level using 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Fusion Imaging (18F-FDG PET/CT) in Primary Breast CancerJapanese Journal of Clinical Oncology, 2008
- Invasive Micropapillary Carcinoma of the BreastAmerican Journal of Clinical Pathology, 2006
- Invasive Micropapillary Carcinoma of the Breast : Association of Pathologic Features With Lymph Node MetastasisAmerican Journal of Clinical Pathology, 2006
- Invasive Micropapillary Carcinoma of the Breast: Clinical, Mammographic, and Sonographic Findings with Histopathologic CorrelationAmerican Journal of Roentgenology, 2002
- Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast CarcinomaLaboratory Investigation, 2001
- Fine Needle Aspiration Cytology of Invasive Micropapillary Carcinoma of the BreastActa Cytologica, 2000
- The HER-2/neu oncogene: prognostic factor, predictive factor and target for therapySeminars in Cancer Biology, 1999
- Estrogen and Progesterone Receptors, C-ERBB-2, p53, and BCL-2 in Thirty-three Invasive Micropapillary Breast CarcinomasPathology - Research and Practice, 1996