LDL subclass phenotypes and triglyceride metabolism in non-insulin-dependent diabetes.
- 1 December 1992
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
- Vol. 12 (12), 1496-1502
- https://doi.org/10.1161/01.atv.12.12.1496
Abstract
Plasma low density lipoprotein (LDL) comprises multiple discrete subclasses differing in size, density, and chemical composition. A common, heritable phenotype characterized by the predominance of small, dense LDL particles (LDL subclass phenotype B) is associated with relatively increased concentrations of plasma triglycerides, reduced levels of high density lipoprotein, and increased risk of coronary artery disease in comparison with subjects with larger LDL (LDL subclass phenotype A). Population studies have indicated that approximately 20-30% of adult men have phenotype B, and another 15-20% have LDL of intermediate size. The lipid changes in phenotype B are similar to those that have been observed in patients with non-insulin-dependent diabetes mellitus (NIDDM). In the present study, we have assessed LDL subclass phenotypes in normolipidemic men with NIDDM and in age-matched control subjects who had similar lipid levels. There was a greater than twofold increase in the percentage of individuals with the LDL B phenotype in the NIDDM subjects. The LDL B phenotype was associated with higher plasma triglyceride levels and a trend toward lower high density lipoprotein cholesterol levels compared with the LDL A phenotype in the NIDDM subjects, as has been previously observed in control groups. Indices of diabetic control, such as fasting and hemoglobin A1 levels, were similar regardless of LDL phenotype pattern, suggesting that glycemic control was not likely to account for the increase in the LDL B phenotype. In both control and NIDDM subjects, the clearance of triglyceride-rich lipoproteins was slowed in the subjects with the LDL phenotype B compared with those with the A phenotype.(ABSTRACT TRUNCATED AT 250 WORDS)Keywords
This publication has 37 references indexed in Scilit:
- Influence of obesity, impaired glucose tolerance, and NIDDM on LDL structure and composition. Possible link between hyperinsulinemia and atherosclerosisDiabetes, 1990
- Effect of proteoglycans on lipoprotein-cell interactions: possible contribution to atherogenesisCurrent Opinion in Lipidology, 1990
- Abnormal Lipoprotein Composition in Normolipidemic Diabetic PatientsDiabetes Care, 1990
- Quantitative Relationship Between Plasma Lipids and Glycohemoglobin in Type I Patients: Longitudinal Study of 212 PatientsDiabetes Care, 1989
- Improvement of the Plasma Lipoprotein Pattern After Institution of Insulin Treatment in Diabetes MellitusDiabetes Care, 1982
- Hyperglycemia and Plasma Lipid Levels: Covariations in Insulin-dependent DiabetesDiabetes Care, 1982
- Relationships Between Control and Serum Lipids in Juvenile-onset DiabetesDiabetes Care, 1981
- Human serum lipoproteins. Evidence for three classes of lipoproteins in SfO-2Biochemistry, 1972
- Equilibrium banding of low-density lipoproteins III. Studies on normal individuals and the effects of diet and heparin-induced lipaseBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1970
- Composition and structure of plasma lipoproteins. Isolation, composition, and immunochemical characterization of low density lipoprotein subfractions of human plasmaBiochemistry, 1970