Effect of frequent dosing of an oral proton pump inhibitor on intragastric pH
Open Access
- 12 May 2006
- journal article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 23 (11), 1607-1613
- https://doi.org/10.1111/j.1365-2036.2006.02933.x
Abstract
Summary Background Treatment with a continuous i.v. proton pump inhibitor is presumed to promote clot formation and stability by sustaining intragastric pH ≥ 6. Aim We postulated that very frequent oral dosing of proton pump inhibitors should simulate i.v. infusion and achieve similar pH control. Methods Twenty healthy volunteers were stratified by Helicobacter pylori status (10 positive; 10 negative) and had determination of CYP2C19 status. After an overnight fast, an intragastric pH probe was placed. Subjects received 120 mg of lansoprazole at 8 am and 30 mg every 3 h until 8 pm. Intragastric pH was measured over 24 h, and lansoprazole plasma concentrations were determined at five time points. Results Intragastric pH was ≥6 for 41% (95% CI: 30–53%) of the 15‐h period from 8 am–11 pm and 46% (95% CI: 35–56%) of the 24‐h period (8–8 am). The mean proportion of patients with pH ≥6 was not significantly different in H. pylori‐positive vs. negative patients. Only 25% of subjects sustained pH ≥6 for at least 60% of the 15‐h period, and 35% had a sustained pH ≥6 for at least 60% of the 24‐h period. Conclusions A dose of 120 mg of oral lansoprazole followed by standard 30 mg doses of lansoprazole every 3 h did not reliably sustain pH at the desired level of 6.Keywords
This publication has 22 references indexed in Scilit:
- Establishing a Regimen for Lansoprazole Administration to Markedly Inhibit Acid Output in Normal VolunteersGastroenterology, 2005
- Systematic review and meta‐analysis: enhanced efficacy of proton‐pump inhibitor therapy for peptic ulcer bleeding in Asia – a post hoc analysis from the Cochrane CollaborationAlimentary Pharmacology & Therapeutics, 2005
- Effect of oral omeprazole in reducing re‐bleeding in bleeding peptic ulcers: a prospective, double‐blind, randomized, clinical trialAlimentary Pharmacology & Therapeutics, 2003
- Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic UlcersNew England Journal of Medicine, 2000
- Dose–response relationship of lansoprazole to gastric acid antisecretory effectsAlimentary Pharmacology & Therapeutics, 1998
- A Comparison of Omeprazole and Placebo for Bleeding Peptic UlcerNew England Journal of Medicine, 1997
- Effects of aging and gastritis on gastric acid and pepsin secretion in humans: A prospective studyGastroenterology, 1996
- Pharmacological manipulation of gastric juice: thrombelastographic assessment and implications for treatment of gastrointestinal haemorrhage.Gut, 1995
- Bleeding Peptic UlcerNew England Journal of Medicine, 1994
- Clot lysis by gastric juice: an in vitro study.Gut, 1989