Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster
Top Cited Papers
- 24 March 2009
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 106 (12), 4805-4809
- https://doi.org/10.1073/pnas.0801766106
Abstract
The blood cells, or hemocytes, in Drosophila participate in the immune response through the production of antimicrobial peptides, the phagocytosis of bacteria, and the encapsulation of larger foreign particles such as parasitic eggs; these immune reactions are mediated by phylogenetically conserved mechanisms. The encapsulation reaction is analogous to the formation of granuloma in vertebrates, and is mediated by large specialized cells, the lamellocytes. The origin of the lamellocytes has not been formally established, although it has been suggested that they are derived from the lymph gland, which is generally considered to be the main hematopoietic organ in the Drosophila larva. However, it was recently observed that a subepidermal population of sessile blood cells is released into the circulation in response to a parasitoid wasp infection. We set out to analyze this phenomenon systematically. As a result, we define the sessile hemocytes as a novelKeywords
This publication has 18 references indexed in Scilit:
- Definition ofDrosophilahemocyte subsets by cell-type specific antigensActa Biologica Hungarica, 2007
- Drosophila haematopoiesisCellular Microbiology, 2007
- Nimrod, a Putative Phagocytosis Receptor with EGF Repeats in Drosophila PlasmatocytesCurrent Biology, 2007
- A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursorsNature, 2007
- Sterile wounding is a minimal and sufficient trigger for a cellular immune response in Drosophila melanogasterImmunology Letters, 2005
- TheDrosophilalymph gland as a developmental model of hematopoiesisDevelopment, 2005
- Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytesOncogene, 2004
- Cellular Immune Response to Parasitization in Drosophila Requires the EBF Orthologue CollierPLoS Biology, 2004
- Thicker Than BloodDevelopmental Cell, 2003
- Drosophila innate immunity: an evolutionary perspectiveNature Immunology, 2002