Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated
- 1 October 2000
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 131 (4), 663-665
- https://doi.org/10.1038/sj.bjp.0703642
Abstract
The cannabinoid (CB) receptor agonist WIN55,212-2 (500 nM) had no effect on the first of a pair of population spikes evoked in the CA1 region of hippocampal slices prepared from young adult (4 - 6 weeks old) rats, despite powerfully reducing paired-pulse depression. In contrast WIN55,212-2 caused a substantial depression of the single population spike (reduced to 43% control) and the field EPSP (reduced to 72% of control) recorded in slices prepared from neonatal (10 - 13 days old) rats. This effect was stereoselective and blocked by the CB(1) receptor antagonist AM281 (500 nM). The results indicate that activation of CB(1) receptors inhibits excitatory synaptic transmission in neonatal, but not adult rat hippocampus. This developmental regulation of CB(1) receptor mediated control of excitatory transmission may help explain some, but not all, of the previous discrepancies in the literature.Keywords
This publication has 10 references indexed in Scilit:
- Functional expression of cell surface cannabinoid CB1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neuronsNeuroscience, 2000
- Mechanisms of Cannabinoid Inhibition of GABAASynaptic Transmission in the HippocampusJournal of Neuroscience, 2000
- Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons.Journal of Neurophysiology, 1999
- Mechanism of Cannabinoid Effects on Long-Term Potentiation and Depression in Hippocampal CA1 NeuronsJournal of Neuroscience, 1999
- Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing GABAergic interneurons in the rat hippocampal formationNeuroscience, 1999
- Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal InterneuronsJournal of Neuroscience, 1999
- Effects of the endogeneous cannabinoid, anandamide, on neuronal activity in rat hippocampal slicesBritish Journal of Pharmacology, 1999
- Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal sliceNeuropharmacology, 1998
- Cannabinoid Receptor Agonists Inhibit Glutamatergic Synaptic Transmission in Rat Hippocampal CulturesJournal of Neuroscience, 1996
- Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptorsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1995