Effect of polysaccharides extract of rhizoma atractylodis macrocephalae on thymus, spleen and cardiac indexes, caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein and mRNA expression levels in aged rats
- 10 July 2012
- journal article
- Published by Springer Science and Business Media LLC in Molecular Biology Reports
- Vol. 39 (10), 9285-9290
- https://doi.org/10.1007/s11033-012-1677-x
Abstract
This study was designed to determine the possible protective effect of polysaccharides extract of rhizoma atractylodis macrocephalae on heart function in aged rats. Polysaccharides extract of rhizoma atractylodis macrocephalae was administered to aged rats. Results showed that thymus, spleen and cardiac indexs were significantly increased, whereas caspase-3 activity ratio, Smac/DIABLO and HtrA2/Omi protein expression, Smac/DIABLO and HtrA2/Omi mRNA expression levels were markedly reduced. It can be concluded that polysaccharides extract of rhizoma atractylodis macrocephalae may enhance immunity and improve heart function in aged rats.Keywords
This publication has 25 references indexed in Scilit:
- Thymus transplantationClinical Immunology, 2010
- Livin promotes Smac/DIABLO degradation by ubiquitin–proteasome pathwayCell Death & Differentiation, 2006
- Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1Nucleic Acids Research, 2006
- Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced ApoptosisJournal of Biological Chemistry, 2003
- Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase InteractionOnline Journal of Public Health Informatics, 2002
- Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP InhibitionCell, 2000
- Programmed cell death in the developing heartCardiovascular Research, 2000
- Caspase Inhibition Reduces Myocyte Cell Death Induced by Myocardial Ischemia and Reperfusion In VivoJournal of Molecular and Cellular Cardiology, 1999
- Caspases: Enemies WithinScience, 1998
- Sensory neurons regulate immunoglobulin secretion of spleen cells: cellular analysis of bidirectional communications between neurons and immune cellsJournal of Neuroimmunology, 1996