The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
Open Access
- 20 June 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Basic and Clinical Andrology
- Vol. 28 (1), 7
- https://doi.org/10.1186/s12610-018-0072-4
Abstract
The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. There is mounting evidence from studies in human and rodent, that the NL plays an important role in mammalian spermatid differentiation during spermiogenesis. In this review, we summarize and discuss the data available in the literature regarding the involvement of lamins and their direct or indirect partners in normal and abnormal human spermiogenesis.Keywords
Funding Information
- Agence de la Biomédecine (AOR AMP 2013)
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