Proteomics of Pancreatic Cancer
- 1 May 2008
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pancreas
- Vol. 36 (4), 329-336
- https://doi.org/10.1097/mpa.0b013e31815cc452
Abstract
Pancreatic cancer is a devastating disease, with a mortality rate almost identical with its incidence. Late diagnosis and limited therapeutic options make early detection of pancreatic cancer a pressing clinical problem. In this context, the investigation of the pancreatic cancer proteome has recently gained considerable attention because profiles of proteins may be able to more accurately identify disease states, such as cancer. Recent pancreatic cancer proteome studies may be categorized into basic studies cataloguing the pancreatic proteome, studies investigating differential protein expression patterns, and studies searching for proteome-based biomarkers for early cancer detection and differentiation. Although these studies clearly demonstrate that a range of biological samples are suitable for proteomic analyses, comparison of different studies is problematic due to the diversity of methodologies, sample sources, and characterization of patient populations. Reproducibility between studies has rarely been investigated, and no investigation has compared the different methods of proteomic research. The results of this review have shown that more stringent requirements concerning the design and the analysis of future studies should be implemented. These include an adequate patient number, obligatory histological examination of tissues, appropriate control groups, identification of proteins and peaks, validation of differential expression using independent cohorts and/or a second methodology, and, finally, demonstration of result reproducibility. This will hopefully lead to the discovery of prognostic and predictive biomarkers that help to improve prognosis of pancreatic cancer patients.Keywords
This publication has 37 references indexed in Scilit:
- Proteins Associated with Disease and Clinical Course in Pancreas Cancer: A Proteomic Analysis of Plasma in Surgical PatientsJournal of Proteome Research, 2006
- The role of epigenetic alterations in pancreatic cancerJournal of Hepato-Biliary-Pancreatic Surgery, 2006
- Proteomic Classification of Pancreatic Adenocarcinoma Tissue Using Protein Chip TechnologyGastroenterology, 2006
- Pancreatic Cancer Proteome: The Proteins That Underlie Invasion, Metastasis, and Immunologic EscapeGastroenterology, 2005
- Molecular prognostic markers in pancreatic cancer: A systematic reviewEuropean Journal of Cancer, 2005
- Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissueProteomics, 2004
- Prognostic Nomogram for Patients Undergoing Resection for Adenocarcinoma of the PancreasAnnals of Surgery, 2004
- Surgical treatment of pancreatic adenocarcinoma: actual survival and prognostic factors in 343 patientsEuropean Journal of Cancer, 2004
- Two-dimensional protein database of human pancreasElectrophoresis, 2004
- Application of laser capture microdissection combined with two‐dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinomaProteomics, 2003