Manipulation and Overstretching of Genes on Solid Substrates
- 19 March 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 4 (4), 577-579
- https://doi.org/10.1021/nl035147d
Abstract
A “molecular chip”, i.e., a chip on which single macromolecules are freely arranged, is a key for the fabrication of nanoscopic molecular devices, e.g., DNA molecular array chips. We report on a new method for the manipulation of already deposited single macromolecules, which allows to freely position single polyelectrolytes such as DNA on a substrate, to bend and stretch them, to remove stretching defects, and to overstretch double stranded DNA into two parallel single strands.Keywords
This publication has 15 references indexed in Scilit:
- Ten years of tension: single-molecule DNA mechanicsNature, 2003
- Nanoscale chemical analysis by tip-enhanced Raman spectroscopyChemical Physics Letters, 2000
- Nanoscale Science of Single Molecules Using Local ProbesScience, 1999
- Single Molecule Force Spectroscopy on Polysaccharides by Atomic Force MicroscopyScience, 1997
- The Shape of Mars and the Topographic Signature of the Hemispheric DichotomyScience, 1996
- Alignment and Sensitive Detection of DNA by a Moving InterfaceScience, 1994
- Self-assembled alkane monolayers on MoSe2 and MoS2Applied Physics Letters, 1993
- Anisotropic molecular dynamics in the vicinity of order-disorder transitions in organic monolayersPhysical Review Letters, 1992
- Dislocations and Flux Pinning inYBa 2 Cu 3 O 7-δScience, 1991
- Positioning single atoms with a scanning tunnelling microscopeNature, 1990