Subclasses of Human Immunoglobulin A Based on Differences in the Alpha Polypeptide Chains
- 5 August 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 153 (3736), 647-649
- https://doi.org/10.1126/science.153.3736.647
Abstract
Antiserum from goats immunized with heavy polypeptide chains from a γA-type myeloma globulin was absorbed with serum from patients with selective absence of immunoglobulin A (γA). The resulting reagents could be used for the classification of 58 γA-myeloma proteins into two distinct antigenic types, respectively called subclasses He and Le. These differences were shown to be related to the heavy (alpha) polypeptide chains and independent of the integrity of interchain disulfide bridges. The γA-immunoglobulin from normal serum appears to consist, for the most part, of molecules with Le subclass specificity.This publication has 10 references indexed in Scilit:
- GM AND INV FACTORS IN SUBCLASSES OF HUMAN IGGThe Journal of Experimental Medicine, 1965
- DISTRIBUTION AMONG THE γ-GLOBULIN MOLECULES OF DIFFERENT GENETICALLY DETERMINED ANTIGENIC SPECIFICITIES IN THE GM SYSTEMThe Journal of Experimental Medicine, 1965
- On the significance of the heterogeneity in molecular size of human serum γA-globulinsImmunochemistry, 1965
- Antigenic Heterogeneity of Waldenström Type γM‐GlobulinsScandinavian Journal of Haematology, 1965
- INDIVIDUAL ANTIGENIC SPECIFICITY OF MYELOMA PROTEINSThe Journal of Experimental Medicine, 1965
- A NEW CLASS OF HUMAN IMMUNOGLOBULINSThe Journal of Experimental Medicine, 1965
- Subclasses of Human γ 2 -Globulin Based on Differences in the Heavy Polypeptide ChainsScience, 1964
- H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S γ-GLOBULINThe Journal of Experimental Medicine, 1964
- Gamma Globulin Antigenic Types Defined by Heavy Chain DeterminantsScience, 1964
- A Relationship between the H Chain Groups of 7S Γ-Globulin and the Gm SystemNature, 1964