The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
Open Access
- 1 August 2020
- journal article
- research article
- Published by Elsevier BV in Cell Reports
- Vol. 32 (5), 107985
- https://doi.org/10.1016/j.celrep.2020.107985
Abstract
No abstract availableKeywords
Funding Information
- Swiss National Science Foundation (150690, 179057)
- European Research Council (ERC-2016-STG 714326)
- Swiss Cancer Research Foundation (KFS-4406-02-2018)
- UZH Candoc and Postdoc programs
This publication has 58 references indexed in Scilit:
- CHFR is important for the first wave of ubiquitination at DNA damage sitesNucleic Acids Research, 2012
- Fiji: an open-source platform for biological-image analysisNature Methods, 2012
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics DataCancer Discovery, 2012
- CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and DegradationJournal of Biological Chemistry, 2012
- Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitinationGenes & Development, 2012
- Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damageProceedings of the National Academy of Sciences of the United States of America, 2011
- RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signallingNature, 2011
- Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trialThe Lancet, 2010
- Transcription-independent ARF regulation in oncogenic stress-mediated p53 responsesNature, 2010
- The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA DamageCell, 2009