Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94
- 1 January 1993
- journal article
- research article
- Published by Springer Science and Business Media LLC in Somatic Cell and Molecular Genetics
- Vol. 19 (1), 73-81
- https://doi.org/10.1007/bf01233956
Abstract
The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2 → q24.3), and 15 (q25 → q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designatedTRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 andTRAP2) appear to be independently derived, processed pseudogenes.Keywords
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