Reversal of Parenteral Nutrition–Associated Liver Disease in Two Infants With Short Bowel Syndrome Using Parenteral Fish Oil: Implications for Future Management
- 1 July 2006
- journal article
- case report
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 118 (1), e197-e201
- https://doi.org/10.1542/peds.2005-2662
Abstract
Here we report the reversal of cholestasis in 2 infants with intestinal failure and parenteral nutrition–associated liver disease. Treatment involved the substitution of a conventional intravenous fat emulsion with one containing primarily omega-3 fatty acids. Biochemical tests of liver function improved significantly. One child was removed from the liver transplantation list because of improved hepatic function, and the second child had complete resolution of cholestasis while solely on parenteral nutrition. This suggests that fat emulsions made from fish oils may be an effective means of treating and preventing this often-fatal condition. A randomized, controlled trial is necessary to study the efficacy of this new approach to parenteral nutrition–associated liver disease.Keywords
This publication has 23 references indexed in Scilit:
- Use of a fish oil-based lipid emulsion to treat essential fatty acid deficiency in a soy allergic patient receiving parenteral nutritionClinical Nutrition, 2005
- The route of lipid administration affects parenteral nutrition–induced hepatic steatosis in a mouse modelJournal of Pediatric Surgery, 2005
- The role of enteral nutrition in the reversal of parenteral nutrition–associated liver dysfunction in infantsJournal of Pediatric Surgery, 2005
- Neonatal short bowel syndrome: A cohort studyJournal of Pediatric Surgery, 2005
- Use of Cholecystokinin-Octapeptide for the Prevention of Parenteral Nutrition-Associated CholestasisPEDIATRICS, 2005
- A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertensionThe FASEB Journal, 2004
- Steatohepatitis: A tale of two “hits”?Gastroenterology, 1998
- Parenteral nutrition—Related cholestasis in postsurgical neonates: Multivariate analysis of rick factorsJournal of Pediatric Surgery, 1996
- Total Parenteral Nutrition CathetersJournal of Parenteral and Enteral Nutrition, 1994
- Pathogenesis of hepatic steatosis in the parenterally fed rat.JCI Insight, 1984