Structure and functions of arrestins
Open Access
- 1 September 1994
- journal article
- review article
- Published by Wiley in Protein Science
- Vol. 3 (9), 1355-1361
- https://doi.org/10.1002/pro.5560030901
Abstract
Transmembrane signal transductions in a variety of cell types that mediate signals as diverse as those carried by neurotransmitters, hormones, and sensory signals share basic biochemical mechanisms that include: (1) an extracellular perturbation (neurotransmitter, hormone, odor, light); (2) specific receptors; (3) coupling proteins, such as G proteins; and (4) effector enzymes or ion channels. Parallel to these amplification reactions, receptors are precisely inactivated by mechanisms that involve protein kinases and regulatory proteins called arrestins. The structure and functions of arrestins are the focus of this review.Keywords
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