The Use of Live Attenuated Bacteria as a Delivery System for Heterologous Antigens
- 1 January 2003
- journal article
- review article
- Published by Informa UK Limited in Journal of Drug Targeting
- Vol. 11 (8-10), 471-479
- https://doi.org/10.1080/10611860410001670008
Abstract
Live attenuated mutants of several pathogenic bacteria have been exploited as potential vaccine vectors for heterologous antigen delivery by the mucosal route. Such live vectors offer the advantage of potential delivery in a single oral, intranasal or inhalational dose, stimulating both systemic and mucosal immune responses. Over the years, a range of strategies have been developed to allow controlled and stable delivery of antigens and improved immunogenicity where required. Most of these approaches have been evaluated in Salmonella vaccine vectors and, as a result, several live attenuated recombinant Salmonella vaccines are now in human clinical trials. In this review, these strategies and their use in the development of a delivery system for the Yersinia pestis V antigen are described.Keywords
This publication has 22 references indexed in Scilit:
- Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plagueVaccine, 2003
- IEM101, a naturally attenuated Vibrio cholerae strain as carrier for genetically detoxified derivatives of cholera toxinVaccine, 2000
- Plasmid maintenance inEscherichia coli recombinant cultures is dramatically, steadily, and specifically influenced by features of the encoded proteinsBiotechnology & Bioengineering, 1998
- phoP/phoQ-Deleted Salmonella typhi (Ty800) Is a Safe and Immunogenic Single Dose Typhoid Fever Vaccine in VolunteersThe Journal of Infectious Diseases, 1996
- Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.Proceedings of the National Academy of Sciences of the United States of America, 1996
- Expression of fragment C of tetanus toxin fused to a carboxyl-terminal fragment of diphtheria toxin in Salmonella typhi CVD 908 vaccine strainVaccine, 1995
- Macrophage-inducible expression of a model antigen in Salmonella typhimurium enhances immunogenicity.Proceedings of the National Academy of Sciences, 1995
- Expression and immunogenicity of the V3 loop from the envelope of human immunodeficiency virus type 1 in an attenuated aroA strain of Salmonella typhimurium upon genetic coupling to two Escherichia coli carrier proteinsVaccine, 1993
- Use of the nirB Promoter to Direct the Stable Expression of Heterologous Antigens in Salmonella Oral Vaccine Strains: Development of a Single–Dose Oral Tetanus VaccineNature Biotechnology, 1992
- Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinantsNature, 1987