Molecular Mechanisms of Vascular Permeability in Diabetic Retinopathy
- 1 January 1999
- journal article
- review article
- Published by Informa UK Limited in Seminars in Ophthalmology
- Vol. 14 (4), 240-248
- https://doi.org/10.3109/08820539909069543
Abstract
Diabetes leads to a wide array of complications in humans, including kidney failure, vascular disease, peripheral nerve degeneration, and vision loss. Diabetic retinopathy causes blindness in more working-age people in the United States than any other disease and contributes greatly to blindness in the young and old as well. The increasing rate of diabetes occurring in our society can only bring about a further decrease in the visual health of this country unless new modalities are discovered to prevent and cure diabetic retinopathy. Breakdown of the blood-retinal barrier and the resultant vascular permeability remains one of the first observable alterations in diabetic retinopathy and strongly correlates with vision loss. In this article, we examine the molecular components that form this blood-retinal barrier and explore how changes in the production of growth factors in the neural parenchyma cause an increase in vascular permeability and contribute to retinal degeneration.Keywords
This publication has 50 references indexed in Scilit:
- Organization of kinases, phosphatases, and receptor signaling complexesJCI Insight, 1999
- Openings Through Endothelial Cells Associated with Increased Microvascular PermeabilityMicrocirculation, 1999
- Pathways of Macromolecular Extravasation Across Microvascular Endothelium in Response to VPF/VEGF and Other Vasoactive MediatorsMicrocirculation, 1999
- Endothelial Gaps as Sites for Plasma Leakage in InflammationMicrocirculation, 1999
- Expression of Zonula Occludens and Adherens Junctional Proteins in Human Venous and Arterial Endothelian Cells: Role of Occludin in Endothelial Solute BarriersMicrocirculation, 1998
- Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea‐fig, mouse and rat: many are transcellular poresThe Journal of Physiology, 1997
- Effects of Tyrosine Phosphorylation on Tight Junctions in Temperature-Sensitive v-src-transfected MDCK Cells.Cell Structure and Function, 1995
- FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASEThe Journal of cell biology, 1967
- Studies on the permeability of the blood-retinal barrier. I. On the existence, development, and site of a blood-retinal barrier.British Journal of Ophthalmology, 1966
- JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIAThe Journal of cell biology, 1963