Long-term outcomes in healthy adults after radiofrequency ablation of T1a renal tumours
- 8 November 2013
- journal article
- Published by Wiley in BJU International
- Vol. 113 (1), 51-55
- https://doi.org/10.1111/bju.12366
Abstract
To report the long-term oncological and renal function outcomes in healthy adults treated with radiofrequency ablation (RFA) for small renal masses. We retrospectively analysed the medical records of otherwise healthy patients (those with American Society of Anesthesiologists symptom score 1 or 2) with clinical T1a renal tumours who underwent RFA at our institution between March 2001 and July 2012. Radiographic follow-up with contrast imaging was performed at 6 weeks, 6 months, 1 year and annually thereafter. Local recurrence was defined as any new enhancing lesion (>10 HU) after the initial negative post-treatment computed tomography results. The estimated glomerular filtration rates (eGFRs) before and after RFA were calculated using the Cockgroft-Gault equation. We performed RFA on 58 renal tumours in 52 patients. The mean tumour size was 2.2 cm with a median (interquartile range) follow-up of 60 (48-90) months. Three (5.1%) of the treated masses had tumour recurrence after initial RFA. The 5- and 10-year recurrence-free survival rate was 94.2%. There were no recurrences after 3 years. Three (5.1%) patients died during the follow-up, which gave 5- and 10-year overall survival rates of 95.7% and 91.1%. No patient developed metastatic renal cell carcinoma (RCC) and none died from RCC. Paired analysis showed that the eGFR values at a median follow-up of 40 months did not differ significantly from those before RFA. With long-term follow-up, RFA provides durable oncological and functional outcomes for selected T1a renal tumours in otherwise healthy patients.Keywords
This publication has 20 references indexed in Scilit:
- Evaluation and Management of the Renal MassMedical Clinics of North America, 2011
- Radiofrequency ablation of small renal cortical tumours in healthy adults: renal function preservation and intermediate oncological outcomeBJU International, 2009
- Guideline for Management of the Clinical T1 Renal MassJournal of Urology, 2009
- Radical Nephrectomy for pT1a Renal Masses May be Associated With Decreased Overall Survival Compared With Partial NephrectomyJournal of Urology, 2008
- Renal Function Outcomes in Patients Treated for Renal Masses Smaller Than 4 cm by Ablative and Extirpative TechniquesJournal of Urology, 2008
- Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort studyThe Lancet Oncology, 2006
- Nephron-Sparing Surgery for Renal Cell Carcinoma: Detailed Analysis of Complications Over a 15-Year PeriodEuropean Urology, 2006
- LONG-TERM FOLLOWUP OF PATIENTS WITH RENAL CELL CARCINOMA TREATED WITH RADIO FREQUENCY ABLATION WITH CURATIVE INTENTJournal of Urology, 2005
- Imaging-Guided Percutaneous Radiofrequency Ablation of Solid Renal Masses: Techniques and Outcomes of 38 Treatment Sessions in 32 Consecutive PatientsAmerican Journal of Roentgenology, 2003
- LONG-TERM RESULTS OF NEPHRON SPARING SURGERY FOR LOCALIZED RENAL CELL CARCINOMA: 10-YEAR FOLLOWUPJournal of Urology, 2000