Determinants of health-related quality of life in women with vertebral fractures
Open Access
- 9 December 2005
- journal article
- Published by Springer Science and Business Media LLC in Osteoporosis International
- Vol. 17 (3), 355-363
- https://doi.org/10.1007/s00198-005-2020-3
Abstract
Health-related quality of life (HRQL) is an important consideration in the management of patients with vertebral fractures. The purpose of this study was to examine patient-related factors that contribute to HRQL after vertebral fractures, including co-morbidities, medications, fracture history, family disease history, demographics, exercise, education and living environment. A total of 1,129 post-menopausal women (mean age 67.2, SD 11.9 years) was studied from the Canadian Database of Osteoporosis and Osteopenia (CANDOO). HRQL was measured using the mini-osteoporosis quality of life questionnaire (mini-OQLQ). Separate multivariable linear regression analyses [parameter estimates and corresponding 95% confidence intervals (CI)] were performed for each of the five mini-OQLQ domains: symptoms, physical functioning, emotional functioning, activities of daily living and leisure domains. A strong positive association was found between HRQL and post-secondary education, a family history of osteoporosis, working and thiazide therapy. Exercise improved HRQL; however, several hours a week were required to be meaningful. Living in long-term care had the most marked negative effect on HRQL. Smoking, past surgery of the hip or spine, sedatives, anticonvulsants, atherosclerotic disease and hypertension were also associated with a substantially decreased HRQL across several domains. Calcium channel-blockers, chemotherapy, corticosteroids, diabetes, migraines, the number of non-vertebral fractures and falls had a negative impact on selected domains. We demonstrated that several modifiable factors influence HRQL in patients with vertebral fractures, and physicians should be aware of these and other markers of reduced HRQL to enhance patient care.Keywords
This publication has 67 references indexed in Scilit:
- Health-related quality of life after osteoporotic fracturesOsteoporosis International, 2004
- Health-related quality of life during treatment of elderly patients with hypertension: results from the Study on COgnition and Prognosis in the Elderly (SCOPE)Journal of Human Hypertension, 2004
- The Impact of Fragility Fracture on Health-Related Quality of LifeDrugs & Aging, 2004
- Efficacy of home-based exercise for improving quality of life among elderly women with symptomatic osteoporosis-related vertebral fracturesOsteoporosis International, 2003
- Adverse Outcomes of Osteoporotic Fractures in the General PopulationJournal of Bone and Mineral Research, 2003
- Adverse Impact of Cigarette Smoking on Dimensions of Health-Related Quality of Life in Persons with HIV InfectionAIDS Patient Care and STDs, 2001
- Health-Related Quality of Life in Postmenopausal Women With Low BMD With or Without Prevalent Vertebral FracturesJournal of Bone and Mineral Research, 2000
- Epidemiology of Spinal OsteoporosisSpine, 1997
- The MOS 36-ltem Short-Form Health Survey (SF-36)Medical Care, 1992
- Measuring change over time: Assessing the usefulness of evaluative instrumentsJournal of Chronic Diseases, 1987