Administration of Excitatory Amino Acid Antagonists via Microdialysis Attenuates the Increase in Glucose Utilization Seen following Concussive Brain Injury
Open Access
- 1 January 1992
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 12 (1), 12-24
- https://doi.org/10.1038/jcbfm.1992.3
Abstract
Immediately following concussive brain injury, cells exhibit an increase of energy demand represented by the activation of glucose utilization. We have proposed that this trauma-induced hypermetabolism reflects the effort of cells to restore normal ionic balance disrupted by massive ionic fluxes through transmitter-gated ion channels. In the present study, changes in local CMRglc following fluid-percussion concussive injury were determined using [14C]2-deoxy-d-glucose autoradiography, and the effects of in situ administration (via microdialysis) of excitatory amino acid (EAA) antagonists [kynurenic acid (KYN), 2-amino-5-phosphonovaleric acid (APV; 100 μM, 1 mM, and 10 mM), and 6-cyano-7-nitroquinoxaline-2,3-dine (CNQX; 300 μM, 1 mM, and 10 mM] on glucose utilization were investigated. Animals that did not receive dialysis showed a remarkable increase (up to 181% of normal control) in cortical glucose utilization following injury. In contrast, this high demand for glucose was reduced in areas infiltrated w...Keywords
This publication has 66 references indexed in Scilit:
- Brain Acidosis in Experimental Pneumococcal MeningitisJournal of Cerebral Blood Flow & Metabolism, 1989
- Experimental fluid percussion brain injury: vascular disruption and neuronal and glial alterationsBrain Research, 1989
- Isolated Stimulation of Glycolysis Following Traumatic Brain InjuryPublished by Springer Science and Business Media LLC ,1989
- Evidence for a specific role for cortical NMDA receptors in slow-wave sleepBrain Research, 1988
- Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonistsJournal of Neuroscience, 1988
- Electrophysiological studies of NMDA receptorsTrends in Neurosciences, 1987
- Ionic dependence of glutamate neurotoxicityJournal of Neuroscience, 1987
- Threshold effects of N-methyl D-aspartate (NMDA) and 2-amino 5-phosphono valeric acid (2APV) on the spontaneous activity of neocortical single neurones in the urethane anaesthetised ratExperimental Brain Research, 1985
- Energy-requiring cell functions in the ischemic brainJournal of Neurosurgery, 1982
- Oxygen and glucose consumption related to Na+-K+ transport in canine brain.Stroke, 1981