Insulin‐like growth factor I supports differentiation of cultured osteoblast‐like cells
Open Access
- 23 July 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 173 (1), 48-52
- https://doi.org/10.1016/0014-5793(84)81015-7
Abstract
Rat calvaria cells grown in culture for one week had properties of osteoblasts: a high content in alkaline phosphatase and a marked cyclic AMP response to parathyroid hormone (PTH). In short‐term experiments, insulin‐like growth factor I (IGFI) stimulated the incorporation of (14C]glucose into glycogen. When IGF I was present in the medium during 6 days the cell number increased slightly and there was a substantial, disproportionate rise in alkaline phosphatase activity of the cultures. Thus, IGFI stimulates growth, and in addition, and in contrast to other growth factors, mainly enhances differentiation of osteoblasts.Keywords
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