PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics
Top Cited Papers
- 27 August 2012
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 12 (10), 5304-5310
- https://doi.org/10.1021/nl302638g
Abstract
In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a long-circulating particle was dramatically less than what has been previously reported. Overall, our methodology provides a rapid screening technique to predict particle behavior in vivo and our results deliver further insight to what PEG density is necessary to facilitate long-circulation.Keywords
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