Catch-up Alveolarization in Ex-Preterm Children. Evidence from 3He Magnetic Resonance
- 15 May 2013
- journal article
- research article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 187 (10), 1104-1109
- https://doi.org/10.1164/rccm.201210-1850oc
Abstract
Rationale: Histologic data from fatal cases suggest that extreme prematurity results in persisting alveolar damage. However, there is new evidence that human alveolarization might continue throughout childhood and could contribute to alveolar repair. Objectives: To examine whether alveolar damage in extreme-preterm survivors persists into late childhood, we compared alveolar dimensions between schoolchildren born term and preterm, using hyperpolarized helium-3 magnetic resonance. Methods: We recruited schoolchildren aged 10–14 years stratified by gestational age at birth (weeks) to four groups: (1) term-born (37–42 wk; n = 61); (2) mild preterm (32–36 wk; n = 21); (3) extreme preterm (Measurements and Main Results: The two extreme preterm groups had a lower FEV1 (P = 0.017) compared with term-born and mild preterm children. Apparent diffusion coefficient was 0.092 cm2/second (95% confidence interval, 0.089–0.095) in the term group. Corresponding values were 0.096 (0.091–0.101), 0.090 (0085–0.095), and 0.089 (0.083–0.094) in the mild preterm and two extreme preterm groups, respectively, implying comparable alveolar dimensions across all groups. Results did not change after controlling for anthropometric variables and potential confounders. Conclusions: Alveolar size at school age was similar in survivors of extreme prematurity and term-born children. Because extreme preterm birth is associated with deranged alveolar structure in infancy, the most likely explanation for our finding is catch-up alveolarization.This publication has 44 references indexed in Scilit:
- Evidence for Adult Lung Growth in HumansThe New England Journal of Medicine, 2012
- Alveolarization Continues during Childhood and AdolescenceAmerican Journal of Respiratory and Critical Care Medicine, 2012
- Lung Function and Respiratory Symptoms at 11 Years in Children Born Extremely PretermAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarizationAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2010
- Quantitative Histological Validation of Diffusion MRI Fiber Orientation Distributions in the Rat BrainPLOS ONE, 2010
- Quantification of lung microstructure with hyperpolarized 3He diffusion MRIJournal of Applied Physiology, 2009
- Survival of extremely premature babies in a geographically defined population: prospective cohort study of 1994-9 compared with 2000-5BMJ, 2008
- A parent-completed respiratory questionnaire for 1-year-old children: repeatabilityArchives of Disease in Childhood, 2007
- Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysemaMagnetic Resonance in Medicine, 2006
- The postnatal development and growth of the human lung. II. MorphologyRespiration Physiology, 1987