Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?
- 1 May 1987
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 243 (3), 803-808
- https://doi.org/10.1042/bj2430803
Abstract
Free-radical attack upon uric acid generates allantoin [Ames, Cathcart, Schwiers & Hochstein (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 6858-6862]. Methods are described for the accurate measurement of uric acid and allantoin in human body fluids. The concentrations of uric acid and allantoin in human serum and synovial fluid are reported. It is suggested that measurement of changes in allantoin concentration may be a useful index of free-radical reactions taking place in vivo.Keywords
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