Smart multi-channel two-dimensional micro-gas chromatography for rapid workplace hazardous volatile organic compounds measurement
- 1 January 2013
- journal article
- Published by Royal Society of Chemistry (RSC) in Lab on a Chip
- Vol. 13 (5), 818-825
- https://doi.org/10.1039/c2lc41159h
Abstract
We developed a novel smart multi-channel two-dimensional (2-D) micro-gas chromatography (μGC) architecture that shows promise to significantly improve 2-D μGC performance. In the smart μGC design, a non-destructive on-column gas detector and a flow routing system are installed between the first dimensional separation column and multiple second dimensional separation columns. The effluent from the first dimensional column is monitored in real-time and decision is then made to route the effluent to one of the second dimensional columns for further separation. As compared to the conventional 2-D μGC, the greatest benefit of the smart multi-channel 2-D μGC architecture is the enhanced separation capability of the second dimensional column and hence the overall 2-D GC performance. All the second dimensional columns are independent of each other, and their coating, length, flow rate and temperature can be customized for best separation results. In particular, there is no more constraint on the upper limit of the second dimensional column length and separation time in our architecture. Such flexibility is critical when long second dimensional separation is needed for optimal gas analysis. In addition, the smart μGC is advantageous in terms of elimination of the power intensive thermal modulator, higher peak amplitude enhancement, simplified 2-D chromatogram re-construction and potential scalability to higher dimensional separation. In this paper, we first constructed a complete smart 1 × 2 channel 2-D μGC system, along with an algorithm for automated control/operation of the system. We then characterized and optimized this μGC system, and finally employed it in two important applications that highlight its uniqueness and advantages, i.e., analysis of 31 workplace hazardous volatile organic compounds, and rapid detection and identification of target gas analytes from interference background.Keywords
This publication has 20 references indexed in Scilit:
- Adaptive Two-Dimensional Microgas ChromatographyAnalytical Chemistry, 2012
- Demonstration of motionless Knudsen pump based micro-gas chromatography featuring micro-fabricated columns and on-column detectorsLab on a Chip, 2011
- Solid phase extraction in combination with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry for the detailed investigation of volatiles in South African red winesAnalytica Chimica Acta, 2011
- Fabry−Pérot Cavity Sensors for Multipoint On-Column Micro Gas Chromatography DetectionAnalytical Chemistry, 2010
- Microfabricated thermal modulator for comprehensive two-dimensional micro gas chromatography: design, thermal modeling, and preliminary testingLab on a Chip, 2010
- Highly versatile fiber-based optical Fabry-Pérot gas sensorOptics Express, 2009
- Stop‐flow comprehensive two‐dimensional gas chromatography with pneumatic switchingJournal of Separation Science, 2008
- Comparison of one-dimensional and comprehensive two-dimensional separations by gas chromatographyJournal of Chromatography A, 2008
- Information technologies for comprehensive two-dimensional gas chromatographyChemometrics and Intelligent Laboratory Systems, 2004
- Compehensive two‐dimensional gas chromatography (GC×GC) and its applicability to the characterization of complex (petrochemical) mixturesJournal of High Resolution Chromatography, 1997