Concurrent chemoradiotherapy for locally advanced unresectable adenoid cystic carcinoma of head and neck: experience from a single institute
- 9 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Archives Of Oto-Rhino-Laryngology
- Vol. 278 (11), 4423-4431
- https://doi.org/10.1007/s00405-021-06654-3
Abstract
Purpose To analyze the outcome of locally advanced unresectable adenoid cystic carcinoma (ACC) of head and neck treated with radical concurrent chemoradiotherapy (CRT) at a single tertiary care centre. Methods Between 2011 and 2018, 23 patients with locally advanced unresectable ACC of head and neck treated with non-surgical radical treatment with concurrent chemoradiotherapy were evaluated for outcome and toxicity. All but one patient received cisplatin-based concurrent chemotherapy and 74% of patients were treated with intensity-modulated radiotherapy. Results Median follow-up was 53 months (range 3–115 months). Following treatment, 11 patients achieved complete response (47.8%) and of the 12 patients with residual disease, 7 patients additionally had disease stabilization without local progression. Overall 15 patients had disease progression. Median time to progression was 28 months (range 6–67 months). The 3-year and 5-year overall survival, local progression-free survival (LPFS) and distant progression-free survival (DPFS) were 78%, 79.7%, 67.4% and 63%, 50.9%, 48.6%, respectively. Acute grade 3 mucositis was observed in three patients, and one patient additionally developed grade 4 neutropenia with subsequent complete recovery. No grade 3 or higher late toxicity was observed. Conclusion Radical concurrent chemoradiotherapy is a promising treatment option in locally advanced unresectable ACC with acceptable toxicity.Keywords
This publication has 39 references indexed in Scilit:
- Treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neckOral Oncology, 2012
- Adenoid cystic carcinoma of the head and neckCancer, 2012
- Adenoid cystic carcinoma of the head and neckAmerican Journal of Otolaryngology, 2012
- Role of radiotherapy in adenoid cystic carcinoma of the head and neckThe Journal of Laryngology & Otology, 2009
- Intraoral adenoid cystic carcinoma: Prognostic factors and outcomeOral Oncology, 2008
- Outcomes and Prognostic Variables in Adenoid Cystic Carcinoma of the Head and Neck: A Recent ExperienceInternational Journal of Radiation Oncology*Biology*Physics, 2007
- Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxelInternational Journal of Clinical Oncology, 2006
- Systemic Therapy in the Palliative Management of Advanced Salivary Gland CancersJournal of Clinical Oncology, 2006
- Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neckHead & Neck, 2004
- Adenoid cystic carcinoma of major and minor salivary gland originThe Laryngoscope, 1984