First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy
- 12 May 2009
- journal article
- research article
- Published by International Union of Crystallography (IUCr) in Journal of Synchrotron Radiation
- Vol. 16 (4), 587-590
- https://doi.org/10.1107/s0909049509012485
Abstract
The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated. (C) 2009 International Union of Crystallography Printed in Singapore - all rights reservedKeywords
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