Comparison of Low Molecular Weight Heparin vs. Unfractionated Heparin in Gynecological Surgery
- 11 January 1988
- journal article
- clinical trial
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 67 (2), 99-103
- https://doi.org/10.3109/00016348809004178
Abstract
In a double-blind, randomized trial, the antithrombotic effect and haemorrhagic complications of low molecular weight heparin (LMWH) (Heparin fragment 2165, KabiVitrum) and unfractionated heparin (UH) were compared. LMWH (5000 anti-XaU) was injected every 24 h, UH (5000 IU) every 12 h; both drugs by subcutaneous injection. During 1984-85, 215 patients were examined clinically and by plethysmography. Venography was performed whenever DVT was suspected. None of the patients proved to have DVT. Bleeding complications were found in 54% of the cases. The LMWH group had a statistically significant predominance of bleeding complications as reflected by wound haematomas (p = 0.02) and the number of blood transfusions (p = 0.02). The heparin concentration was higher in the LMWH group (mean 0.13 IU/ml) than in the UH group (mean 0.13 IU/ml) measured 2 h after the injection. In the doses administered, LMWH and UH seem effective in the prevention of thrombosis. The increased bleeding tendency in the LMWH group probably was a consequence of the to high dosage.Keywords
This publication has 8 references indexed in Scilit:
- Anticoagulant effects of two types of low molecular weight heparin administered subcutaneouslyThrombosis Research, 1983
- The effect of low-dose heparin on blood loss at abdominal hysterectomyBJOG: An International Journal of Obstetrics and Gynaecology, 1983
- The relationship between the hemorrhagic and antithrombotic properties of low molecular weight heparin in rabbitsBlood, 1982
- Anticoagulant and antithrombotic effects of heparin and low molecular weight heparin fragments in rabbitsThrombosis Research, 1982
- Embolieletalität nach gynäkologischen Operationen - Klinische Erfahrungen ohne AntikoagulantienGeburtshilfe und Frauenheilkunde, 1981
- KINETICS IN NORMAL HUMANS OF ANTICOAGULANT ACTIVITY, RADIOACTIVITY AND LIPOLYTIC ACTIVITY AFTER INTRAVENOUS ADMINISTRATION OF (S35, HEPARIN AND (S35 HEPARIN FRACTIONSScandinavian Journal of Haematology, 1980
- Bleeding in Gynecological Surgery: Influence of Low Dose HeparinInternational Journal of Gynecology & Obstetrics, 1976
- A COMPARISON OF LOW‐DOSE SUBCUTANEOUS HEPARIN AND INTRAVENOUS DEXTRAN 70 IN THE PROPHYLAXIS OF DEEP VENOUS THROMBOSIS AFTER GYNAECOLOGICAL SURGERYBJOG: An International Journal of Obstetrics and Gynaecology, 1974