Pharmacokinetics of linezolid in bone tissue investigated by in vivo microdialysis
- 1 January 2008
- journal article
- Published by Informa UK Limited in Scandinavian Journal of Infectious Diseases
- Vol. 40 (1), 24-29
- https://doi.org/10.1080/00365540701509873
Abstract
Pharmacokinetics of unbound anti-infectives in bone is difficult to characterize. The aim of this study was to assess the feasibility of the microdialysis technique to cancellous bone for single dose pharmacokinetic investigations of the anti-infective linezolid. Serial bone biopsies (left tibia) and microdialysate samples (right tibia: 2 catheters) as well as plasma and bone marrow samples were obtained from 10 pigs. The concentrations of linezolid reached bacteriostatic levels in plasma, bone marrow, bone biopsies and microdialysates. With the use of microdialysis we here present the first results for unbound linezolid bone penetration. Unbound linezolid concentrations in bone obtained by microdialysis were lower than might have been expected from previous bone biopsy studies. To achieve effective concentrations (24 h) for susceptible organisms the chosen dose of linezolid might not be sufficient.Keywords
This publication has 19 references indexed in Scilit:
- Pharmacokinetics of Unbound Linezolid in Plasma and Tissue Interstitium of Critically Ill Patients after Multiple Dosing Using MicrodialysisAntimicrobial Agents and Chemotherapy, 2006
- Application of microdialysis to cancellous bone tissue for measurement of gentamicin levelsJournal of Antimicrobial Chemotherapy, 2004
- Tissue pharmacokinetics of levofloxacin in human soft tissue infectionsBritish Journal of Clinical Pharmacology, 2004
- LinezolidPenetration into Bone and Joint Tissues Infected withMethicillin-ResistantStaphylococciAntimicrobial Agents and Chemotherapy, 2003
- Clinical Pharmacokinetics of Linezolid, a Novel Oxazolidinone AntibacterialClinical Pharmacokinetics, 2003
- In situ gentamicin concentrations in cortical boneAn experimental study using microdialysis in boneActa Orthopaedica, 2003
- Science, medicine, and the future: MicrodialysisBMJ, 2002
- Impaired target site penetration of β -lactams may account for therapeutic failure in patients with septic shockCritical Care Medicine, 2001
- LinezolidDrugs, 2001
- In situ microdialysis in bone tissue. Stimulation of prostaglandin E2 release by weight-bearing mechanical loading.JCI Insight, 1996