RELEASE OF BIOACTIVE SUBSTANCES FROM FORMULATIONS CONTAINING ARTHROSPIRA PLATENSIS (SPIRULINA PLATENSIS)
- 31 October 2018
- journal article
- research article
- Published by Polish Pharmaceutical Society in Acta Poloniae Pharmaceutica - Drug Research
- Vol. 75 (5), 1187-1199
- https://doi.org/10.32383/appdr/85111
Abstract
Arthrospira platensis (Spirulina platensis) is a well-known microalga and has been utilized as a medicinal agent and foodstuff by humans since at least 16th century. The aim of this study was to determine zinc content as well as determine phenolic and indole compounds from commercial preparations containing Arthrospira platensis (lyophilizate, tablets, and capsules) before and after extraction with methanol and incubation with artificial digestive juices. The secondary aim of this study was to evaluate the quality of these preparations. The samples were incubated in artificial stomach juice and in intestinal juice. The samples were mineralized and their zinc(II) ions content was estimated using flame absorption atomic spectroscopy (F-AAS). The maximum zinc(II) ions content released into the digestive juices was found to be up to 1.6 mg/100 g of the preparation. Phenolic compounds identified in the examined extracts are as follows: gallic acid; protocatechuic acid; 3,4-dihydroxyphenylacetic acid; p-hydroxybenzoic acid; syringic acid; cinnamic acid; and quercetin. Furthermore, indole compounds identified were 5-hydroxy-L-tryptophan, 5-methyl-L-tryptophan, L-tryptophan, tryptamine, and 5-methyltryptamine. Consequently, it was also found that the distributed Arthrospira platensis in the form of tablets does not disintegrate in the artificial digestive juices. Among the examined preparations, only hard capsules met the requirements of the European Pharmacopeia 8th ed.Keywords
This publication has 9 references indexed in Scilit:
- INFLUENCE OF EXTRACTION PROCEDURE FROM EDIBLE MUSHROOM SPECIES BOLETUS BADIUS ON ZINC QUANTITY RELEASED INTO SIMULATED GASTRIC FLUID2017
- Heavy metal analysis in commercial Spirulina products for human consumptionSaudi Journal of Biological Sciences, 2013
- Comparison of the therapeutic effects of extracts from Spirulina platensis and amnion membrane on inflammation-associated corneal neovascularization2012
- Antibacterial activity of crude extracts of Spirulina platensis and its structural elucidation of bioactive compoundJournal of Medicinal Plants Research, 2011
- Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae SpirulinaCardiovascular Therapeutics, 2010
- Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential usesFood Chemistry, 2006
- Efficacy of Spirulina Extract Plus Zinc in Patients of Chronic Arsenic Poisoning: A Randomized Placebo-Controlled StudyClinical Toxicology, 2006
- Polyphenols: food sources and bioavailabilityThe American Journal of Clinical Nutrition, 2004
- Trace elements in human physiology and pathology: zinc and metallothioneinsBiomedicine & Pharmacotherapy, 2003