THE EFFECTS OF 6-MERCAPTOPURINE ON HOMOGRAFT REACTIONS *
- 1 June 1960
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 39 (6), 952-958
- https://doi.org/10.1172/jci104116
Abstract
The mean rejection time of skin grafts in rabbits was 6.8 days. When rabbits were treated with 6-mercaptopurine, 12 mg/kilo/day, the mean rejection time was 17.8 days. Intermediate doses also prolonged the retention of the homografts. No effect of 6-mercaptopurine treatment was found on the 2d set homograft reaction. These studies indicate that 6-mercaptopurine not only suppresses antibody formation to purified antigens, but also to homografts.Keywords
This publication has 13 references indexed in Scilit:
- Effect of Cytotoxic Agents on Antibody ProductionNature, 1960
- THE EFFECT OF 6-MERCAPTOPURINE ON PRIMARY AND SECONDARY IMMUNE RESPONSES *JCI Insight, 1959
- Transplantation of homologous bone marrow and skin from common multiple donors following total body irradiation.1959
- Drug-induced Immunological ToleranceNature, 1959
- Relationships Between Lymphocytic Choriomeningitis Virus, Amethopterin, and an Amethopterin-Resistant Lymphocytic Neoplasm in MiceJNCI Journal of the National Cancer Institute, 1959
- Effect of 8-Azaguanine on Antibody Synthesis in vitroNature, 1958
- Effect of 6-Mercaptopurine on Antibody Production.Experimental Biology and Medicine, 1958
- THE ACUTE EFFECTS OF BETA-3-THIENYLALANINE IN THE ADULT MALE ALBINO RAT - OBSERVATIONS ON NITROGEN BALANCE, ANTIBODY FORMATION, AND TUMOR GROWTH1956
- The immunology of transplantation.1956
- Implantation of Functional Erythropoietic Elements Following Total-Body Irradiation.Experimental Biology and Medicine, 1955