Co-morbid obsessive–compulsive disorder and depression: a Bayesian network approach
- 5 January 2017
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 47 (7), 1204-1214
- https://doi.org/10.1017/s0033291716003287
Abstract
Background: Obsessive–compulsive disorder (OCD) is often co-morbid with depression. Using the methods of network analysis, we computed two networks that disclose the potentially causal relationships among symptoms of these two disorders in 408 adult patients with primary OCD and co-morbid depression symptoms.Method: We examined the relationship between the symptoms constituting these syndromes by computing a (regularized) partial correlation network via the graphical LASSO procedure, and a directed acyclic graph (DAG) via a Bayesian hill-climbing algorithm.Results: The results suggest that the degree of interference and distress associated with obsessions, and the degree of interference associated with compulsions, are the chief drivers of co-morbidity. Moreover, activation of the depression cluster appears to occur solely through distress associated with obsessions activating sadness – a key symptom that ‘bridges’ the two syndromic clusters in the DAG.Conclusions: Bayesian analysis can expand the repertoire of network analytic approaches to psychopathology. We discuss clinical implications and limitations of our findings.Keywords
This publication has 39 references indexed in Scilit:
- Network analysis of depression and anxiety symptom relationships in a psychiatric samplePsychological Medicine, 2016
- Revealing the dynamic network structure of the Beck Depression Inventory-IIPsychological Medicine, 2015
- Network Analysis: An Integrative Approach to the Structure of PsychopathologyAnnual Review of Clinical Psychology, 2013
- qgraph: Network Visualizations of Relationships in Psychometric DataJournal of Statistical Software, 2012
- The pathoplasticity of dysphoric episodes: differential impact of stressful life events on the pattern of depressive symptom inter-correlationsPsychological Medicine, 2011
- Comorbidity: A network perspectiveBehavioral and Brain Sciences, 2010
- Extended Bayesian information criteria for model selection with large model spacesBiometrika, 2008
- Psychometric perspectives on diagnostic systemsJournal of Clinical Psychology, 2008
- Effects of comorbid depression on response to treatment for obsessive-compulsive disorderBehavior Therapy, 2000
- A cognitive approach to panicBehaviour Research and Therapy, 1986