Metal-Free Oxidative C(sp3)–H Bond Thiolation of Ethers with Disulfides
- 30 August 2013
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 15 (18), 4654-4657
- https://doi.org/10.1021/ol402281f
Abstract
A novel method for the preparation of alkyl aryl sulfides through direct oxidation thiolation of commercial ethers with diaryl disulfides using di-tert-butyl peroxide (DTBP) as the oxidant without a metal catalyst was established. The C(sp3)–H bond in various ethers was successfully converted into a C–S bond, and the corresponding sulfides were achieved with moderate to high yields.Keywords
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