Natural regulatory T cells in autoimmunity
- 29 July 2010
- journal article
- review article
- Published by Taylor & Francis Ltd in Autoimmunity
- Vol. 44 (1), 33-42
- https://doi.org/10.3109/08916931003782155
Abstract
The suppressive/immunomodulatory function of CD4+CD25+FOXP3+ regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.Keywords
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