Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)–Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
Open Access
- 3 March 2016
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 213 (10), 1557-1561
- https://doi.org/10.1093/infdis/jiw080
Abstract
With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclonal antibody m336, which has high neutralizing activity against MERS-CoV in vitro. m336 was administered to rabbits intravenously or intranasally before infection with MERS-CoV. Prophylaxis with m336 resulted in a reduction of pulmonary viral RNA titers by 40–9000-fold, compared with an irrelevant control antibody with little to no inflammation or viral antigen detected. This protection in rabbits supports further clinical development of m336.Funding Information
- the Division of Intramural Research
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health (NIH)
- National Cancer Institute
- NIH
This publication has 12 references indexed in Scilit:
- Animal models of Middle East respiratory syndrome coronavirus infectionAntiviral Research, 2015
- Direct Administration in the Respiratory Tract Improves Efficacy of Broadly Neutralizing Anti-Influenza Virus Monoclonal AntibodiesAntimicrobial Agents and Chemotherapy, 2015
- Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infectionProceedings of the National Academy of Sciences of the United States of America, 2015
- Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in RabbitsJournal of Virology, 2015
- Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi ArabiaInternational Journal of Infectious Diseases, 2014
- Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal AntibodiesJournal of Virology, 2014
- Real-Time Reverse Transcription-PCR Assay Panel for Middle East Respiratory Syndrome CoronavirusJournal of Clinical Microbiology, 2014
- Hospital Outbreak of Middle East Respiratory Syndrome CoronavirusNew England Journal of Medicine, 2013
- Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive studyThe Lancet Infectious Diseases, 2013
- Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodiesProceedings of the National Academy of Sciences of the United States of America, 2007