Immediate‐type hypersensitivity to polyethylene glycols: a review
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- 21 June 2016
- journal article
- research article
- Published by Wiley in Clinical & Experimental Allergy
- Vol. 46 (7), 907-922
- https://doi.org/10.1111/cea.12760
Abstract
Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. Though generally considered biologically inert, cases of mild to life-threatening immediate-type PEG hypersensitivity are reported with increasing frequency. Nevertheless awareness of PEG's allergenic potential remains low, due to a general lack of suspicion towards excipients and insufficient product labeling. Information on immediate-type reactions to PEG is limited to anecdotal reports, and the potential for PEG-sensitization and cross-sensitization to PEGylated drugs and structurally related derivatives is likely underestimated. Most healthcare professionals have no knowledge of PEG and thus do not suspect PEG's as culprit agents in hypersensitivity reactions. In consequence, patients are at risk of misdiagnosis and commonly present with a history of repeated, severe reactions to a range of unrelated products in hospital and at home. Increased awareness of PEG prevalence, PEG hypersensitivity and improved access to PEG allergy testing should facilitate earlier diagnosis and reduce the risk of inadvertent re-exposure. This first comprehensive review provides practical information for allergists and other health care professionals by describing the clinical picture of 37 reported cases of PEG hypersensitivity since 1977, summarizing instances where PEG hypersensitivity should be considered and proposing an algorithm for diagnostic management.Keywords
This publication has 59 references indexed in Scilit:
- Hypersensitivity to Polyethylene GlycolsThe Journal of Clinical Pharmacology, 2013
- Urticaria induced by Etoxisclerol® (polidocanol)Journal of the European Academy of Dermatology and Venereology, 2007
- Severe Allergic Eczema due to Pegylated α-Interferon may Abate After Switching to Daily Conventional α-InterferonJournal of Clinical Gastroenterology, 2007
- Angioedema as a hypersensitivity reaction to polyethylene glycol oral electrolyte solutionGastrointestinal Endoscopy, 2006
- Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tabletsAllergy, 2006
- Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactionsAnnals of Allergy, Asthma & Immunology, 2005
- Angioedema from oral polyethylene glycol electrolyte lavage solutionGastrointestinal Endoscopy, 1996
- Urticarial reaction to oral polyethylene glycol electrolyte lavage solutionGastrointestinal Endoscopy, 1992
- Probable anaphylactic reaction to polyethylene glycol electrolyte lavage solutionGastrointestinal Endoscopy, 1991
- Anaphylaktischer Schock nach Einnahme einer LutschtabletteDeutsche Medizinische Wochenschrift (1946), 1990