Potentiometric and Coulometric Determination of Carbimazole
- 1 January 2000
- journal article
- research article
- Published by Informa UK Limited in Analytical Letters
- Vol. 33 (8), 1545-1554
- https://doi.org/10.1080/00032710008543142
Abstract
A method for the determination of carbimazole involving its reaction with iodine in an alkaline medium is presented. In volumetric titration with potentiometric end-point detection the range of determination is 30–500 μmol (5.6–93 mg). In coulometric titration using biamperometric end-point detection, 0.5–20 μmol (0.09–3.7 mg) of carbimazole was successfully determined. The coulometric titration was applied to the determination of carbimazole in tablets.Keywords
This publication has 7 references indexed in Scilit:
- Bromometric determination of carbimazoleTalanta, 1993
- Determination of Methimazole and Carbimazole Using Polarography and VoltammetryAnalytical Letters, 1990
- Polarographic and Spectrophotometric Study of the Base Catalyzed Hydrolysis of CarbimazoleAnalytical Letters, 1990
- Aspects of the analysis of drugs and drug metabolites by high-performance liquid chromatographyThe Analyst, 1981
- The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.British Journal of Clinical Pharmacology, 1980
- Choice of thin-layer chromatographic systems for the routine screening for neutral drugs during toxicological analysesJournal of Chromatography A, 1978
- Colour reactions of 2:6‐dichloroquinone chloroimide with derivatives of glyoxaline‐2‐thiolJournal of Applied Chemistry, 1955