Onyx®: a unique neuroembolic agent
- 1 November 2006
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Review of Medical Devices
- Vol. 3 (6), 705-715
- https://doi.org/10.1586/17434440.3.6.705
Abstract
Rupture of a cerebral arteriovenous malformation can result in devastating hemorrhage with a possibility of serious neurological injury or death. Endovascular embolization is an important adjunct in the treatment of cerebral arteriovenous malformations, and in a small number of cases may provide definitive treatment. Currently available embolic agents have several shortcomings, including the possibility of recanalization, adhesiveness to the endovascular microcatheter and suboptimal handling at the time of surgical resection. Onyx is an ethylene vinyl alcohol copolymer dissolved in dimethyl sulfoxide that was approved by the US FDA in July 2005 as an embolic agent for brain arteriovenous malformations. Although long-term follow-up is limited, this agent appears to offer several advantages over the other available embolic agents for the endovascular management of arteriovenous malformations and other vascular lesions.Keywords
This publication has 22 references indexed in Scilit:
- Complications of Cerebral Arteriovenous Malformation Embolization: Multivariate Analysis of Predictive FactorsNeurosurgery, 2006
- Polymorphisms in Transforming Growth Factor-β-Related Genes ALK1 and ENG Are Associated With Sporadic Brain Arteriovenous MalformationsStroke, 2005
- Liquid embolic agents in the treatment of intracranial arteriovenous malformationsNeurosurgery Clinics of North America, 2005
- Guglielmi Detachable Coil embolization of cerebral aneurysms: 11 years' experienceJournal of Neurosurgery, 2003
- Surgical handling characteristics of an ethylene vinyl alcohol copolymer compared with N-butyl cyanoacrylate used for embolization of vessels in an arteriovenous malformation resection model in swineJournal of Neurosurgery, 2003
- A nonadhesive liquid embolic agent composed of ethylene vinyl alcohol copolymer and ethanol mixture for the treatment of cerebral arteriovenous malformations: experimental studyJournal of Neurosurgery, 2002
- A mixture of ethylene vinyl alcohol copolymer and ethanol yielding a nonadhesive liquid embolic agent to treat cerebral arteriovenous malformations: initial clinical experienceJournal of Neurosurgery, 2002
- Epidemiology and natural history of arteriovenous malformationsNeurosurgical Focus, 2001
- Cure, Morbidity, and Mortality Associated with Embolization of Brain Arteriovenous MalformationsNeurosurgery, 1995
- Embolization of arteriovenous malformations with peripheral aneurysms using ethylene vinyl alcohol copolymerJournal of Neurosurgery, 1991